Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
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چکیده
منابع مشابه
Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis.
Upon apoptotic stimuli, lysosomal proteases, including cathepsins and chymotrypsin, are released into cytosol due to lysosomal membrane permeabilization (LMP), where they trigger apoptosis via the lysosomal-mitochondrial pathway of apoptosis. Herein, the mechanism of LMP was investigated. We found that caspase 8-cleaved Bid (tBid) could result in LMP directly. Although Bax or Bak might modestly...
متن کاملtBID Homooligomerizes in the mitochondrial membrane to induce apoptosis.
Activation of the tumor necrosis factor R1/Fas receptor results in the cleavage of cytosolic BID to truncated tBID. tBID translocates to the mitochondria to induce the oligomerization of BAX or BAK, resulting in the release of cytochrome c (Cyt c). Here we demonstrate that in tumor necrosis factor alpha-activated FL5.12 cells, tBID becomes part of a 45-kDa cross-linkable mitochondrial complex t...
متن کاملUrinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells.
Lysosomal membrane permeabilization (LMP) has been shown to cause the release of cathepsins and other hydrolases from the lysosomal lumen to the cytosol and initiate a cell death pathway. Whether proteinuria triggers LMP in renal tubular epithelial cells (TECs) to accelerate the progression of renal tubulointerstitial injury remains unclear. In the present study, we evaluated TEC injury as well...
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Defensins are cationic antimicrobial peptides that serve as important components of host innate immune defenses, often by targeting cell membranes of pathogens. Oligomerization of defensins has been linked to their antimicrobial activity; however, the molecular basis underpinning this process remains largely unclear. Here we show that the plant defensin NsD7 targets the phospholipid phosphatidi...
متن کاملPhysiological and pathological cell death have been classifi ed according to morphological criteria into at least three categories: type I cell death or apoptosis; type II cell death or autophagic cell death; and type III cell death
This article is available online at http://www.jlr.org Physiological and pathological cell death have been classifi ed according to morphological criteria into at least three categories: type I cell death or apoptosis; type II cell death or autophagic cell death; and type III cell death or necrosis ( 1, 2 ). Lysosomes were known to be involved in autophagy ( 3, 4 ) and, after the massive ruptur...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2012
ISSN: 0022-2275
DOI: 10.1194/jlr.m027557